Open AccessBiomimicking Bone–Implant Interface Facilitates the Bioadaption of a New Degradable Magnesium Alloy to the Bone Tissue Microenvironment
Author(s) -
Li Wenting,
Qiao Wei,
Liu Xiao,
Bian Dong,
Shen Danni,
Zheng Yufeng,
Wu Jun,
Kwan Kenny Y. H.,
Wong Tak Man,
Cheung Kenneth M. C.,
Yeung Kelvin W. K.
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202102035
Subject(s) - implant , mineralization (soil science) , alloy , materials science , calcium , magnesium alloy , magnesium , biomedical engineering , bone tissue , bone matrix , chemistry , metallurgy , anatomy , surgery , medicine , cartilage , organic chemistry , nitrogen
The most critical factor determining the success of biodegradable bone implants is the host tissue response, which greatly depends on their degradation behaviors. Here, a new magnesium‐based implant, namely magnesium–silicon–calcium (Mg–0.2Si–1.0Ca) alloy, that coordinates its biodegradation along with the bone regenerative process via a self‐assembled, multilayered bone–implant interface is designed. At first, its rapid biocorrosion contributes to a burst release of Mg 2+ , leading to a pro‐osteogenic immune microenvironment in bone. Meanwhile, with the simultaneous intervention of Ca and Si in the secondary phases of the new alloy, a hierarchical layered calcified matrix is rapidly formed at the degrading interface that favored the subsequent bone mineralization. In contrast, pure Mg or Mg–0.2Si alloy without the development of this interface at the beginning will unavoidably induce detrimental bone loss. Hence, it is believed this biomimicking interface justifies its bioadaptability in which it can modulate its degradation in vivo and accelerate bone mineralization.