Open AccessA Fully Integrated Closed‐Loop System Based on Mesoporous Microneedles‐Iontophoresis for Diabetes Treatment
Author(s) -
Li Xiangling,
Huang Xinshuo,
Mo Jingshan,
Wang Hao,
Huang Qiqi,
Yang Cheng,
Zhang Tao,
Chen HuiJiuan,
Hang Tian,
Liu Fanmao,
Jiang Lelun,
Wu Qianni,
Li Hongbo,
Hu Ning,
Xie Xi
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202100827
Subject(s) - transdermal , iontophoresis , insulin delivery , biomedical engineering , closed loop , drug delivery , materials science , wearable computer , nanotechnology , computer science , diabetes mellitus , medicine , pharmacology , embedded system , type 1 diabetes , control engineering , engineering , radiology , endocrinology
A closed‐loop system that can mini‐invasively track blood glucose and intelligently treat diabetes is in great demand for modern medicine, yet it remains challenging to realize. Microneedles technologies have recently emerged as powerful tools for transdermal applications with inherent painlessness and biosafety. In this work, for the first time to the authors' knowledge, a fully integrated wearable closed‐loop system (IWCS) based on mini‐invasive microneedle platform is developed for in situ diabetic sensing and treatment. The IWCS consists of three connected modules: 1) a mesoporous microneedle‐reverse iontophoretic glucose sensor; 2) a flexible printed circuit board as integrated and control; and 3) a microneedle‐iontophoretic insulin delivery component. As the key component, mesoporous microneedles enable the painless penetration of stratum corneum, implementing subcutaneous substance exchange. The coupling with iontophoresis significantly enhances glucose extraction and insulin delivery and enables electrical control. This IWCS is demonstrated to accurately monitor glucose fluctuations, and responsively deliver insulin to regulate hyperglycemia in diabetic rat model. The painless microneedles and wearable design endows this IWCS as a highly promising platform to improve the therapies of diabetic patients.