Open AccessRecent Advances in Stimulus‐Responsive Nanocarriers for Gene Therapy
Author(s) -
Yu Cheng,
Li Long,
Hu Pei,
Yang Yan,
Wei Wei,
Deng Xin,
Wang Lu,
Tay Franklin R.,
Ma Jingzhi
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202100540
Subject(s) - nanocarriers , nanomedicine , genetic enhancement , gene delivery , nanotechnology , stimulus (psychology) , hypoxia (environmental) , chemistry , neuroscience , bioinformatics , drug delivery , cancer research , gene , materials science , medicine , biology , oxygen , psychotherapist , psychology , biochemistry , nanoparticle , organic chemistry
Gene therapy provides a promising strategy for curing monogenetic disorders and complex diseases. However, there are challenges associated with the use of viral delivery vectors. The advent of nanomedicine represents a quantum leap in the application of gene therapy. Recent advances in stimulus‐responsive nonviral nanocarriers indicate that they are efficient delivery systems for loading and unloading of therapeutic nucleic acids. Some nanocarriers are responsive to cues derived from the internal environment, such as changes in pH, redox potential, enzyme activity, reactive oxygen species, adenosine triphosphate, and hypoxia. Others are responsive to external stimulations, including temperature gradients, light irradiation, ultrasonic energy, and magnetic field. Multiple stimuli‐responsive strategies have also been investigated recently for experimental gene therapy.