Open AccessMagnetophoretic Decoupler for Disaggregation and Interparticle Distance Control
Author(s) -
Kim Hyeonseol,
Lim Byeonghwa,
Yoon Jonghwan,
Kim Keonmok,
Torati Sri Ramulu,
Kim CheolGi
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202100532
Subject(s) - biochip , magnetic field , bead , materials science , nanotechnology , magnetic bead , magnetic tweezers , microfluidics , magnetic nanoparticles , rotating magnetic field , sorting , magnetic separation , superparamagnetism , biological system , magnetization , chemistry , computer science , physics , optical tweezers , chromatography , optics , nanoparticle , composite material , quantum mechanics , metallurgy , biology , programming language
The manipulation of superparamagnetic beads has attracted various lab on a chip and magnetic tweezer platforms for separating, sorting, and labeling cells and bioentities, but the irreversible aggregation of beads owing to magnetic interactions has limited its actual functionality. Here, an efficient solution is developed for the disaggregation of magnetic beads and interparticle distance control with a magnetophoretic decoupler using an external rotating magnetic field. A unique magnetic potential energy distribution in the form of an asymmetric magnetic thin film around the gap is created and tuned in a controlled manner, regulated by the size ratio of the bead with a magnetic pattern. Hence, the aggregated beads are detached into single beads and transported in one direction in an array pattern. Furthermore, the simultaneous and accurate spacing control of multiple magnetic bead pairs is performed by adjusting the angle of the rotating magnetic field, which continuously changes the energy well associated with a specific shape of the magnetic patterns. This technique offers an advanced solution for the disaggregation and controlled manipulation of beads, can allow new possibilities for the enhanced functioning of lab on a chip and magnetic tweezers platforms for biological assays, intercellular interactions, and magnetic biochip systems.