Open AccessA Lubricated Nonimmunogenic Neural Probe for Acute Insertion Trauma Minimization and Long‐Term Signal Recording
Author(s) -
Lee Yeontaek,
Shin Hyogeun,
Lee Dongwon,
Choi Sungah,
Cho IlJoo,
Seo Jungmok
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202100231
Subject(s) - biomedical engineering , gliosis , signal (programming language) , materials science , brain implant , inflammation , brain trauma , medicine , traumatic brain injury , computer science , pathology , programming language , psychiatry
Brain‐machine interfaces (BMIs) that link the brain to a machine are promising for the treatment of neurological disorders through the bi‐directional translation of neural information over extended periods. However, the longevity of such implanted devices remains limited by the deterioration of their signal sensitivity over time due to acute inflammation from insertion trauma and chronic inflammation caused by the foreign body reaction. To address this challenge, a lubricated surface is fabricated to minimize friction during insertion and avoid immunogenicity during neural signal recording. Reduced friction force leads to 86% less impulse on the brain tissue, and thus immediately increases the number of measured signal electrodes by 102% upon insertion. Furthermore, the signal measurable period increases from 8 to 16 weeks due to the prevention of gliosis. By significantly reducing insertion damage and the foreign body reaction, the lubricated immune‐stealthy probe surface (LIPS) can maximize the longevity of implantable BMIs.