Open AccessTopological Encoded Vector Beams for Monitoring Amyloid‐Lipid Interactions in Microcavity
Author(s) -
Gong Chaoyang,
Qiao Zhen,
Yuan Zhiyi,
Huang ShihHsiu,
Wang Wenjie,
Wu Pin Chieh,
Chen YuCheng
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202100096
Subject(s) - lasing threshold , topology (electrical circuits) , laser , photonics , biosensor , photonic crystal , polarization (electrochemistry) , materials science , lipid bilayer , optoelectronics , optics , nanotechnology , membrane , physics , chemistry , biochemistry , mathematics , combinatorics
Lasers are the pillars of modern photonics and sensing. Recent advances in microlasers have demonstrated its extraordinary lasing characteristics suitable for biosensing. However, most lasers utilized lasing spectrum as a detection signal, which can hardly detect or characterize nanoscale structural changes in microcavity. Here the concept of amplified structured light‐molecule interactions is introduced to monitor tiny bio‐structural changes in a microcavity. Biomimetic liquid crystal droplets with self‐assembled lipid monolayers are sandwiched in a Fabry–Pérot cavity, where subtle protein‐lipid membrane interactions trigger the topological transformation of output vector beams. By exploiting Amyloid β (A β )‐lipid membrane interactions as a proof‐of‐concept, it is demonstrated that vector laser beams can be viewed as a topology of complex laser modes and polarization states. The concept of topological‐encoded laser barcodes is therefore developed to reveal dynamic changes of laser modes and A β ‐lipid interactions with different A β assembly structures. The findings demonstrate that the topology of vector beams represents significant features of intracavity nano‐structural dynamics resulted from structured light‐molecule interactions.