Open AccessLimb Development: Atlas of Musculoskeletal Stem Cells with the Soft and Hard Tissue Differentiation Architecture (Adv. Sci. 23/2020)
Author(s) -
Yin Zi,
Lin Junxin,
Yan Ruojin,
Liu Richun,
Liu Mengfei,
Zhou Bo,
Zhou Wenyan,
An Chengrui,
Chen Yangwu,
Hu Yejun,
Fan Chunmei,
Zhao Kun,
Wu Bingbing,
Zou Xiaohui,
Zhang Jin,
ElHashash Ahmed H.,
Chen Xiao,
Ouyang Hongwei
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202070129
Subject(s) - stem cell , population , morphogenesis , soft tissue , anatomy , biology , medicine , microbiology and biotechnology , pathology , genetics , gene , environmental health
In article number 2000938, Zi Yin, Junxin Lin, and co‐workers identify a novel musculoskeletal stem cell population by single‐cell transcriptional profiling with lineage tracing data during limb development. The differentiation potential and trajectory of musculoskeletal stem cells showed they could contribute to soft and hard connective tissues, as well as muscular tissue. These results suggest an indispensable role of limb Scx + musculoskeletal stem cell population in musculoskeletal system morphogenesis.