Open AccessGlycogen Metabolism: IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway (Adv. Sci. 19/2020)
Author(s) -
Zhu Xiaopeng,
Yao Ting,
Wang Ru,
Guo Shanshan,
Wang Xin,
Zhou Zhenqi,
Zhang Yan,
Zhuo Xiaozhen,
Wang Ruitao,
Li John Zhong,
Liu Tiemin,
Kong Xingxing
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202070108
Subject(s) - glycogen , glycogen synthase , skeletal muscle , irf4 , metabolism , endocrinology , glycogen debranching enzyme , medicine , chemistry , biology , biochemistry , transcription factor , gene
Little is known about how glycogen metabolism is manipulated during exercise. In article number 2001502, John Zhong Li, Tiemin Liu, Xingxing Kong, and coworkers identify that interferon regulatory factor 4 (IRF4) in skeletal muscle regulates glycogen metabolism and subsequent exercise capacity. This work reveals a regulatory pathway including IRF4/protein targeting to glycogen (PTG)/glycogen synthesis on controlling exercise capacity.