Open AccessHeavy Metals Impact: Adverse Impact of Heavy Metals on Bone Cells and Bone Metabolism Dependently and Independently through Anemia (Adv. Sci. 19/2020)
Author(s) -
Zhang Shuping,
Sun Li,
Zhang Jie,
Liu Sijin,
Han Jinxiang,
Liu Yajun
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202070106
Subject(s) - anemia , erythropoietin , erythropoiesis , homeostasis , bone remodeling , medicine , ineffective erythropoiesis , iron homeostasis , chemistry , endocrinology , metabolism
In article number 2000383, Jinxiang Han, Yajun Liu, and co‐workers review how heavy metals induce bone damages through anemia‐independent and ‐related routes. Anemia‐independent routes include bone cell dysregulation, bone formation inhibition and bone degradation enhancement, and Ca/P homeostasis disruption. Stress erythropoiesis, erythropoietin deficiency, and disordered iron homeostasis are involved in anemia‐related routes.