Open AccessAntibiotic Therapy: Sublethal Levels of Antibiotics Promote Bacterial Persistence in Epithelial Cells (Adv. Sci. 18/2020)
Author(s) -
Liu Xiaoye,
Liu Fei,
Ding Shuangyang,
Shen Jianzhong,
Zhu Kui
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202070104
Subject(s) - antibiotics , bacteria , microbiology and biotechnology , multidrug tolerance , biology , persistence (discontinuity) , in vivo , antibiotic therapy , extracellular , biofilm , genetics , geotechnical engineering , engineering
In article number 1900840, Jianzhong Shen, Kui Zhu, and co‐workers present how many extracellular bacteria can invade and survive in epithelial cells in both in vivo and in vitro models. Once such bacteria survive in host cells, they act as “Trojan horses” to tolerate various stresses including antibiotic therapy. Such adaption endows bacteria with common tolerance to multiple antibiotics. Sublethal levels of antibiotics not only promote the production of bacterial toxins to increase bacterial invasion, but also cause mitochondrial dysfunction and retard the clearance of internalized bacteria.