Open AccessAntibiotic Resistance: A Macromolecule Reversing Antibiotic Resistance Phenotype and Repurposing Drugs as Potent Antibiotics (Adv. Sci. 17/2020)
Author(s) -
Ding Xin,
Yang Chuan,
Moreira Wilfried,
Yuan Peiyan,
Periaswamy Balamurugan,
Sessions Paola Florez,
Zhao Huimin,
Tan Jeremy,
Lee Ashlynn,
Ong Kai Xun,
Park Nathaniel,
Liang Zhen Chang,
Hedrick James L.,
Yang Yi Yan
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202070094
Subject(s) - antibiotics , antibiotic resistance , microbiology and biotechnology , bacteria , auranofin , in vivo , rifampicin , pharmacology , chemistry , medicine , biology , immunology , rheumatoid arthritis , genetics
In article number 2001374, James L. Hedrick, Yi Yan Yang, and co‐workers show that guanidiniumfunctionalized polycarbonates reverse the antibiotic resistance phenotype, and improve antibiotic potency via intracellular protein precipitation, gene binding and subsequent reactive oxygen species generation. Importantly, the polymer allows for the effective repositioning of rifampicin and auranofin meant for Gram‐positive bacteria and arthritis, respectively, to be highly effective against multidrugresistant Gram‐negative bacteria both in vitro and in vivo.