Open AccessAutophagy Intervention Agents: Iron Oxide Nanoparticles as Autophagy Intervention Agents Suppress Hepatoma Growth by Enhancing Tumoricidal Autophagy (Adv. Sci. 16/2020)
Author(s) -
Xie Yuexia,
Jiang Jiana,
Tang Qianyun,
Zou Hanbing,
Zhao Xue,
Liu Hongmei,
Ma Ding,
Cai Chenlei,
Zhou Yan,
Chen Xiaojing,
Pu Jun,
Liu Peifeng
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202070091
Subject(s) - autophagy , intracellular , in vivo , reactive oxygen species , in vitro , microbiology and biotechnology , chemistry , cancer research , medicine , biology , biochemistry , apoptosis
In article number 1903323, Peifeng Liu and co‐workers identify the carboxy‐functional iron oxide nanoparticle (Fe 2 O 3 @DMSA) as an autophagy intervention agent for the treatment of hepatoma. In‐depth analysis reveals that Fe 2 O 3 @DMSA triggers intracellular iron‐retention‐induced sustained reactive oxygen species production to activate autophagy but block the fusion of autophagosomes and lysosomes, which efficiently inhibits hepatoma growth through enhancing tumoricidal autophagy in vitro and in vivo. Fe 2 O 3 @DMSA shows potential clinical application for hepatoma therapy.