Open AccessAcinetobacter baumannii : Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance (Adv. Sci. 15/2020)
Author(s) -
Zhu Yan,
Lu Jing,
Han MeiLing,
Jiang Xukai,
Azad Mohammad A. K.,
Patil Nitin A.,
Lin YuWei,
Zhao Jinxin,
Hu Yang,
Yu Heidi H.,
Chen Ke,
Boyce John D.,
Dunstan Rhys A.,
Lithgow Trevor,
Barlow Christopher K.,
Li Weifeng,
SchneiderFutschik Elena K.,
Wang Jiping,
Gong Bin,
Sommer Bjorn,
Creek Darren J.,
Fu Jing,
Wang Lushan,
Schreiber Falk,
Velkov Tony,
Li Jian
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202070082
Subject(s) - polymyxin , acinetobacter baumannii , microbiology and biotechnology , acinetobacter , bacterial outer membrane , polymyxin b , colistin , bacteria , chemistry , biology , antibiotics , pseudomonas aeruginosa , escherichia coli , gene , biochemistry , genetics
In article number 2000704, Jian Li and co‐workers elucidate the novel mechanism of dependent resistance to the last‐line polymyxins in a high‐priority “superbug” Acinetobacter baumannii . Polymyxindependent resistance cannot be detected by conventional microbiological diagnosis due to the lack of growth on normal agar plates. These polymyxin‐dependent Acinetobacter baumannii isolates utilize the rigid polymyxin molecules as sticking plasters to stabilize their fragile lipopolysaccharide‐deficient and phosphatidylglycerol‐rich outer membrane.
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