Open AccessHuman Helicase DDX: Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation (Adv. Sci. 14/2020)
Author(s) -
Chen Zijun,
Li Zhengyang,
Hu Xiaojian,
Xie Feiyan,
Kuang Siyun,
Zhan Bowen,
Gao Wenqing,
Chen Xiangjun,
Gao Siqi,
Li Yang,
Wang Yongming,
Qian Feng,
Ding Chen,
Gan Jianhua,
Ji Chaoneng,
Xu XueWei,
Zhou Zheng,
Huang Jinqing,
He Housheng Hansen,
Li Jixi
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202070077
Subject(s) - rna helicase a , helicase , microbiology and biotechnology , rna , virology , chemistry , biology , biochemistry , gene
In article number 2000532, Jixi Li and co‐workers report a set of four crystal structures of human RNA helicase DDX21, revealing dramatic conformational rearrangements during the RNA unwinding cycle. Furthermore, the discovery of small RNAs modulating the interaction between DDX21 and viral protein NS1, generates a fresh perspective toward the virus–host interface, and will be beneficial in developing therapeutics to combat the influenza virus infection.