Open AccessArterial Regeneration: Dimeric Thymosin β4 Loaded Nanofibrous Interface Enhanced Regeneration of Muscular Artery in Aging Body through Modulating Perivascular Adipose Stem Cell–Macrophage Interaction (Adv. Sci. 8/2020)
Author(s) -
Chen Wanli,
Jia Sansan,
Zhang Xinchi,
Zhang Siqian,
Liu Huan,
Yang Xin,
Zhang Cun,
Wu Wei
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202070045
Subject(s) - regeneration (biology) , adipose tissue , stem cell , abdominal aorta , aorta , progenitor cell , medicine , vascular smooth muscle , artery , anatomy , microbiology and biotechnology , biology , smooth muscle
In article number 1903307, Cun Zhang, Wei Wu, and co‐workers identify the adult perivascular adipose tissue (PVAT) as the dominant source of vascular progenitors in a rat abdominal aorta model and clarify the mechanism by which DTβ4 enhances arterial muscle remodeling in the aging body. Different from conventional synthetic grafts, DTβ4‐incorporated grafts exhibit enhanced vascular regenerative activity and effectively ameliorate aging induced defective regeneration, thus providing a rational strategy for clinical translation of vascular grafts.