Open AccessBRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020)
Author(s) -
Chen Qiang,
Lei Josh Haipeng,
Bao Jiaolin,
Wang Haitao,
Hao Wenhui,
Li Licen,
Peng Cheng,
Masuda Takaaki,
Miao Kai,
Xu Jun,
Xu Xiaoling,
Deng ChuXia
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202070033
Subject(s) - mitophagy , autophagy , inflammasome , mitochondrion , metastasis , microbiology and biotechnology , cancer research , reactive oxygen species , mammary tumor , biology , cancer , chemistry , apoptosis , breast cancer , immunology , biochemistry , inflammation , genetics
Mitophagy is a selective autophagic process for clearing damaged mitochondria and maintaining a healthy mitochondrial network. In article number 1903616, Qiang Chen, Chu‐Xia Deng, and co‐workers demonstrate breast cancer susceptibility gene 1 (BRCA1) facilitates mitophagy to eliminate damaged mitochondria and reactive oxygen species through regulating mitochondrial dynamics, thereby blocking inflammasome activation to prevent mammary tumor metastasis.