Open AccessmiRNA Delivery: Tailored Lipoprotein‐Like miRNA Delivery Nanostructure Suppresses Glioma Stemness and Drug Resistance through Receptor‐Stimulated Macropinocytosis (Adv. Sci. 5/2020)
Author(s) -
Jiang Gan,
Chen Huan,
Huang Jialin,
Song Qingxiang,
Chen Yaoxing,
Gu Xiao,
Jiang Zhenhuan,
Huang Yukun,
Lin Yingying,
Feng Junfeng,
Jiang Jiyao,
Bao Yinghui,
Zheng Gang,
Chen Jun,
Chen Hongzhuan,
Gao Xiaoling
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202070025
Subject(s) - sox2 , pinocytosis , glioma , cancer research , microrna , drug delivery , chemistry , microbiology and biotechnology , nanotechnology , receptor , medicine , materials science , biology , endocytosis , biochemistry , transcription factor , gene
In article number 1903290, Jun Chen, Hongzhuan Chen, Xiaoling Gao, and co‐workers synthesize a tailored lipoprotein‐based nanostructure to realize glioma intiating cells (GICs)‐targeted accumulation through a receptor‐stimulated macropinocytosis manner. By carrying RNAi in the core, this tailored nanostructure reduces SOX2 and Notch1 expression, powerfully inhibits GICs stemness and chemoresistance, and significantly prolongs the survival of GICs‐bearing mice, providing a powerful precision nanoplatform to combat glioma.