Open AccessDrug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management
Author(s) -
Makvandi Pooyan,
Josic Uros,
Delfi Masoud,
Pinelli Filippo,
Jahed Vahid,
Kaya Emine,
Ashrafizadeh Milad,
Zarepour Atefeh,
Rossi Filippo,
Zarrabi Ali,
Agarwal Tarun,
Zare Ehsan Nazarzadeh,
Ghomi Matineh,
Kumar Maiti Tapas,
Breschi Lorenzo,
Tay Franklin R
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202004014
Subject(s) - nanocarriers , drug , drug delivery , medicine , cancer , oral cavity , regeneration (biology) , pharmacology , intensive care medicine , dentistry , nanotechnology , materials science , biology , microbiology and biotechnology
The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally‐administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow. For systemically‐administered medications, drug resistance and adverse side‐effects are issues that need to be resolved. New strategies for drug delivery have been investigated over the last decade to overcome these obstacles. Synthesis of nanoparticle‐containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues. Micro/nanoencapsulants with unique structures and properties function as more favorable drug‐release platforms than conventional treatment approaches. The present review provides an overview of newly‐developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine.