Open AccessTriantennary GalNAc Molecular Imaging Probes for Monitoring Hepatocyte Function in a Rat Model of Nonalcoholic Steatohepatitis
Author(s) -
Mishra Anurag,
Castañeda Tamara R.,
Bader Erik,
Elshorst Bettina,
Cummings Sheila,
Scherer Petra,
Bangari Dinesh S.,
Loewe Claudia,
Schreuder Herman,
Pöverlein Christoph,
Helms Mike,
Jones Seth,
Zech Gernot,
Licher Thomas,
Wagner Michael,
Schudok Manfred,
Hoop Meltsje,
Plowright Alleyn T.,
Atzrodt Jens,
Kannt Aimo,
Laitinen Iina,
Derdau Volker
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202002997
Subject(s) - cirrhosis , asialoglycoprotein receptor , nonalcoholic steatohepatitis , nonalcoholic fatty liver disease , hepatocyte , steatosis , medicine , steatohepatitis , liver disease , disease , pathology , cancer research , fatty liver , chemistry , biochemistry , in vitro
Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease that can lead to irreversible liver cirrhosis and cancer. Early diagnosis of NASH is vital to detect disease before it becomes life‐threatening, yet noninvasively differentiating NASH from simple steatosis is challenging. Herein, bifunctional probes have been developed that target the hepatocyte‐specific asialoglycoprotein receptor (ASGPR), the expression of which decreases during NASH progression. The results show that the probes allow longitudinal, noninvasive monitoring of ASGPR levels by positron emission tomography in the newly developed rat model of NASH. The probes open new possibilities for research into early diagnosis of NASH and development of drugs to slow or reverse its progression.