Open AccessNidogen‐1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration
Author(s) -
Zbinden Aline,
Layland Shan L.,
Urbanczyk Max,
Carvajal Berrio Daniel A.,
Marzi Julia,
Zauner Monika,
Hammerschmidt Anne,
Brauchle Eva M.,
Sudrow Katrin,
Fink Simon,
Templin Markus,
Liebscher Simone,
Klein Gerd,
Deb Arjun,
Duffy Garry P.,
Crooks Gay M.,
Eble Johannes A.,
Mikkola Hanna K. A.,
Nsair Ali,
Seifert Martina,
SchenkeLayland Katja
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202002500
Subject(s) - ischemia , angiogenesis , fibrosis , regeneration (biology) , hypoxia (environmental) , medicine , microbiology and biotechnology , infarction , basement membrane , apoptosis , biology , myocardial infarction , chemistry , organic chemistry , oxygen , biochemistry
Ischemia impacts multiple organ systems and is the major cause of morbidity and mortality in the developed world. Ischemia disrupts tissue homeostasis, driving cell death, and damages tissue structure integrity. Strategies to heal organs, like the infarcted heart, or to replace cells, as done in pancreatic islet β ‐cell transplantations, are often hindered by ischemic conditions. Here, it is discovered that the basement membrane glycoprotein nidogen‐1 attenuates the apoptotic effect of hypoxia in cardiomyocytes and pancreatic β ‐cells via the α v β 3 integrin and beneficially modulates immune responses in vitro. It is shown that nidogen‐1 significantly increases heart function and angiogenesis, while reducing fibrosis, in a mouse postmyocardial infarction model. These results demonstrate the protective and regenerative potential of nidogen‐1 in ischemic conditions.