Open AccessBiomass‐Derived Multilayer‐Structured Microparticles for Accelerated Hemostasis and Bone Repair
Author(s) -
Liu JiaYing,
Hu Yang,
Li Long,
Wang Chao,
Wang Jia,
Li Yang,
Chen Dafu,
Ding Xiaokang,
Shen Chuanan,
Xu FuJian
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202002243
Subject(s) - hemostasis , microparticle , biomass (ecology) , biomedical engineering , materials science , medicine , chemical engineering , surgery , biology , engineering , agronomy
It is very desirable to develop advanced sustainable biomedical materials with superior biosafety and bioactivity for clinical applications. Herein, biomass‐derived multilayer‐structured absorbable microparticles (MQ x T y ) composed of starches and plant polyphenols are readily constructed for the safe and effective treatment of bone defects with intractable bleeding by coating multiple layers of quaternized starch (Q + ) and tannic acid onto microporous starch microparticles via facile layer‐by‐layer assembly. MQ x T y microparticles exhibit efficient degradability, low cytotoxicity, and good blood compatibility. Among various MQ x T y microparticles with distinct Q + /T − double layers, MQ 2 T 2 with outmost polyphenol layer possess the unique properties of platelet adhesion/activation and red blood cell aggregation, resulting in the best hemostatic performance. In a mouse cancellous‐bone‐defect model, MQ 2 T 2 exhibits the favorable hemostatic effect, low inflammation/immune responses, high biodegradability, and promoted bone repair. A proof‐of‐concept study of beagles further confirms the good performance of MQ 2 T 2 in controlling intractable bleeding of bone defects. The present work demonstrates that such biomass‐based multilayer‐structured microparticles are very promising biomedical materials for clinical use.