Open AccessBiodegradable Magnesium Alloys Promote Angio‐Osteogenesis to Enhance Bone Repair
Author(s) -
Han HyungSeop,
Jun Indong,
Seok HyunKwang,
Lee KangSik,
Lee Kyungwoo,
Witte Frank,
Mantovani Diego,
Kim YuChan,
GlynJones Sion,
Edwards James R.
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202000800
Subject(s) - biomedical engineering , bone healing , in vivo , regeneration (biology) , angiogenesis , materials science , biodegradable polymer , medicine , surgery , cancer research , polymer , microbiology and biotechnology , biology , composite material
Abstract Biodegradable metallic materials represent a potential step‐change technology that may revolutionize the treatment of broken bones. Implants made with biodegradable metals are significantly stronger than their polymer counterparts and fully biodegradable in vivo, removing the need for secondary surgery or long‐term complications. Here, it is shown how clinically approved Mg alloy promotes improved bone repair using an integrated state of the art fetal mouse metatarsal assay coupled with in vivo preclinical studies, second harmonic generation, secretome array analysis, perfusion bioreactor, and high‐resolution 3D confocal imaging of vasculature within skeletal tissue, to reveal a vascular‐mediated pro‐osteogenic mechanism controlling enhanced tissue regeneration. The optimized mechanical properties and corrosion rate of the Mg alloy lead to a controlled release of metallic Mg, Ca, and Zn ions at a rate that facilitates both angiogenesis and coupled osteogenesis for better bone healing, without causing adverse effects at the implantation site. The findings from this study support ongoing development and refinement of biodegradable metal systems to act as crucial portal technologies with significant potential to improve many clinical applications.