Open AccessManeuvering the Migration and Differentiation of Stem Cells with Electrospun Nanofibers
Author(s) -
Xue Jiajia,
Pisignano Dario,
Xia Younan
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202000735
Subject(s) - nanofiber , stem cell , scaffold , embryonic stem cell , extracellular matrix , induced pluripotent stem cell , mesenchymal stem cell , tissue engineering , microbiology and biotechnology , cellular differentiation , regeneration (biology) , nanotechnology , materials science , biology , biomedical engineering , medicine , biochemistry , gene
Electrospun nanofibers have been extensively explored as a class of scaffolding materials for tissue regeneration, because of their unique capability to mimic some features and functions of the extracellular matrix, including the fibrous morphology and mechanical properties, and to a certain extent the chemical/biological cues. This work reviews recent progress in applying electrospun nanofibers to direct the migration of stem cells and control their differentiation into specific phenotypes. First, the physicochemical properties that make electrospun nanofibers well‐suited as a supporting material to expand stem cells by controlling their migration and differentiation are introduced. Then various systems are analyzed in conjunction with mesenchymal, neuronal, and embryonic stem cells, as well as induced pluripotent stem cells. Finally, some perspectives on the challenges and future opportunities in combining electrospun nanofibers with stem cells are offered to address clinical issues.