Open AccessImmunotherapy: Janus Nanobullets Combine Photodynamic Therapy and Magnetic Hyperthermia to Potentiate Synergetic Anti‐Metastatic Immunotherapy (Adv. Sci. 22/2019)
Author(s) -
Wang Zheng,
Zhang Fan,
Shao Dan,
Chang Zhimin,
Wang Lei,
Hu Hanze,
Zheng Xiao,
Li Xuezhao,
Chen Fangman,
Tu Zhaoxu,
Li Mingqiang,
Sun Wen,
Chen Li,
Dong WenFei
Publication year - 2019
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201970136
Subject(s) - magnetic hyperthermia , immunotherapy , hyperthermia , photodynamic therapy , cancer research , medicine , cytotoxic t cell , immune system , cancer immunotherapy , metastatic breast cancer , magnetic nanoparticles , cancer , chemistry , immunology , materials science , breast cancer , nanotechnology , nanoparticle , biochemistry , organic chemistry , in vitro
In article number 1901690, Dan Shao, Wen Sun, Wen‐Fei Dong, and co‐workers report the development of Janus magnetic nanoparticles for redox/pH‐triggered photo‐sensitizer release with their matrix‐degradation behavior. Cancer cell membrane cloaking improves combined photodynamic therapy and magnetic hyperthermia in a remarkable anticancer manner, which is harnessed for a synergistic tumor‐specific immune response integrated with an anti‐cytotoxic T lymphocyte‐associated antigen‐4 anti‐body for notable eradication of primary and metastatic breast cancer with low systematic toxicity.