Open AccessCollateral Effects: The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells (Adv. Sci. 20/2019)
Author(s) -
Wang Qixue,
Liu Xing,
Zhou Junhu,
Yang Chao,
Wang Guangxiu,
Tan Yanli,
Wu Ye,
Zhang Sijing,
Yi Kaikai,
Kang Chunsheng
Publication year - 2019
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201970124
Subject(s) - crispr , glioma , mutant , cancer research , collateral damage , genome editing , rna , gene , biology , chemistry , genetics , psychology , criminology
In article number 1901299, Chunsheng Kang and co‐workers demonstrate the collateral effect of the CRISPR‐Cas13a system in glioma cells. EGFRvIII is a unique EGFR mutant subtype in glioma, and the CRISPR‐Cas13a system induces death in EGFRvIII‐overexpressing glioma cells. Furthermore, CRISPR‐Cas13a inhibits the formation of glioma intracranial tumors in mice. The results indicate the powerful tumor eliminating potential of this system.