Open AccessDrug Development: A Helical Polypeptide‐Based Potassium Ionophore Induces Endoplasmic Reticulum Stress‐Mediated Apoptosis by Perturbing Ion Homeostasis (Adv. Sci. 14/2019)
Author(s) -
Lee DaeYong,
Lee SooHwan,
Noh Ilkoo,
Oh Eonju,
Ryu Hyunil,
Ha JongHoon,
Jeong SeongDong,
Yoo Jisang,
Jeon TaeJoon,
Yun ChaeOk,
Kim YeuChun
Publication year - 2019
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201970087
Subject(s) - endoplasmic reticulum , cytosol , potassium , homeostasis , ionophore , microbiology and biotechnology , chemistry , apoptosis , oxidative stress , unfolded protein response , biophysics , biochemistry , biology , membrane , enzyme , organic chemistry
In article number of 1801995, Chae‐Ok Yun, Yeu‐Chun Kim, and co‐workers develop helical polypeptide‐based potassium ionophores that can drive out potassium ions from the cytosol. The perturbed potassium homeostasis strongly inflicts endoplasmic reticulum stress to cells and then creates severe oxidative environments, thereby triggering apoptosis. The novel potassium ionophore will be used as a new anticancer agent.