Open AccessPre‐Metastatic Niches: Macrophages‐Triggered Sequential Remodeling of Endothelium‐Interstitial Matrix to Form Pre‐Metastatic Niche in Microfluidic Tumor Microenvironment (Adv. Sci. 11/2019)
Author(s) -
Kim Hyunho,
Chung Hyewon,
Kim Jaehoon,
Choi DongHee,
Shin Yoojin,
Kang Yong Guk,
Kim BeopMin,
Seo SangUk,
Chung Seok,
Seok Seung Hyeok
Publication year - 2019
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201970068
Subject(s) - niche , tumor microenvironment , cancer research , matrix (chemical analysis) , macrophage , metastasis , metastatic tumor , microbiology and biotechnology , chemistry , medicine , biology , cancer , tumor cells , in vitro , biochemistry , chromatography
In article number 1900195 , Seok Chung, Seung Hyeok Seok, and co‐workers take the first step in providing direct evidence of sequential establishment of the pre‐metastatic niche triggered by monocytes and macrophages. The monocytes/macrophages‐mediated remodeling of endothelium‐interstitial matrix leads down a slippery slope for the circulating cancer cells to invade toward metastasis.