Pre‐Metastatic Niches: Macrophages‐Triggered Sequential Remodeling of Endothelium‐Interstitial Matrix to Form Pre‐Metastatic Niche in Microfluidic Tumor Microenvironment (Adv. Sci. 11/2019) | Zendy

Kim Hyunho | Zendy; Chung Hyewon | Zendy; Kim Jaehoon | Zendy; Choi DongHee | Zendy; Shin Yoojin | Zendy; Kang Yong Guk | Zendy; Kim BeopMin | Zendy; Seo SangUk | Zendy; Chung Seok | Zendy; Seok Seung Hyeok | Zendy

Open Access

Pre‐Metastatic Niches: Macrophages‐Triggered Sequential Remodeling of Endothelium‐Interstitial Matrix to Form Pre‐Metastatic Niche in Microfluidic Tumor Microenvironment (Adv. Sci. 11/2019)

Author(s) -

Kim Hyunho,

Chung Hyewon,

Kim Jaehoon,

Choi DongHee,

Shin Yoojin,

Kang Yong Guk,

Kim BeopMin,

Seo SangUk,

Chung Seok,

Seok Seung Hyeok

Publication year - 2019

Publication title -

advanced science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.388

H-Index - 100

ISSN - 2198-3844

DOI - 10.1002/advs.201970068

Subject(s) - niche , tumor microenvironment , cancer research , matrix (chemical analysis) , macrophage , metastasis , metastatic tumor , microbiology and biotechnology , chemistry , medicine , biology , cancer , tumor cells , in vitro , biochemistry , chromatography

In article number 1900195 , Seok Chung, Seung Hyeok Seok, and co‐workers take the first step in providing direct evidence of sequential establishment of the pre‐metastatic niche triggered by monocytes and macrophages. The monocytes/macrophages‐mediated remodeling of endothelium‐interstitial matrix leads down a slippery slope for the circulating cancer cells to invade toward metastasis.

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