Open AccessProtein Corona: Prevention of Dominant IgG Adsorption on Nanocarriers in IgG‐Enriched Blood Plasma by Clusterin Precoating (Adv. Sci. 10/2019)
Author(s) -
Prozeller Domenik,
Pereira Jorge,
Simon Johanna,
Mailänder Volker,
Morsbach Svenja,
Landfester Katharina
Publication year - 2019
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201970062
Subject(s) - nanocarriers , clusterin , antibody , chemistry , chromatography , drug delivery , medicine , immunology , biochemistry , apoptosis , organic chemistry
The development of nanocarriers for drug delivery is challenged by individual blood composition fluctuations. In article number 1802199 , Svenja Morsbach and co‐workers report the accumulation of immunoglobulins in the protein corona of nanocarriers in IgG‐enriched blood plasma resulting in increased cell uptake. This could be prevented by pre‐coating the nanocarriers with the “stealth” protein clusterin. Cover design by Stefan Schuhmacher.