Open AccessOsteosarcoma Therapy: Inhibition of CaMKIIα Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation (Adv. Sci. 8/2019)
Author(s) -
Xu Jing,
Wang Hongsheng,
Hu Yi,
Zhang Yu Shrike,
Wen Longping,
Yin Fei,
Wang Zhuoying,
Zhang Yingchao,
Li Suoyuan,
Miao Yanyan,
Lin Binhui,
Zuo Dongqing,
Wang Gangyang,
Mao Min,
Zhang Tao,
Ding Jianxun,
Hua Yingqi,
Cai Zhengdong
Publication year - 2019
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201970051
Subject(s) - autophagy , fullerene , nanocrystal , osteosarcoma , degradation (telecommunications) , chemistry , cancer research , microbiology and biotechnology , nanotechnology , materials science , medicine , biochemistry , biology , apoptosis , telecommunications , organic chemistry , computer science
In article number 1801233 , Jianxun Ding, Yingqi Hua, Zhengdong Cai, and co‐workers report a combination strategy for improving the efficacy of fullerene C60 nanocrystals in anti‐osteosarcoma therapy. Inhibition of CaMKIIα activity by KN‐93 promotes excessive autophagosome accumulation and autophagic degradation blockage through lysosomal dysfunction induction and further upregulates the anti‐osteosarcoma effect of fullerene C60 nanocrystals.