Open AccessCancer Radiotherapy: Enhanced Radiosensitization by Gold Nanoparticles with Acid‐Triggered Aggregation in Cancer Radiotherapy (Adv. Sci. 8/2019)
Author(s) -
Zhang Yumin,
Huang Fan,
Ren Chunhua,
Liu Jinjian,
Yang Lijun,
Chen Shizhu,
Chang Jinglin,
Yang Cuihong,
Wang Weiwei,
Zhang Chuangnian,
Liu Qiang,
Liang XingJie,
Liu Jianfeng
Publication year - 2019
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201970050
Subject(s) - radiosensitizer , ionizing radiation , colloidal gold , radiation therapy , nanoparticle , chemistry , cancer , nanotechnology , cancer research , irradiation , materials science , medicine , surgery , physics , nuclear physics
In article number 1801806 , Xing‐Jie Liang, Jianfeng Liu, and co‐workers develop a gold nanoparticles (GNPs) system with acid‐triggered aggregation as a radiosensitizer. With a sensitizer enhancement ratio (SER) value of 1.730 (vs. single GNPs of 1.16), this GNPs system improves sensitivity of MCF‐7 cells and MCF‐7 tumor xenograft to ionizing radiation. This work provides a strategy for fabricating radiosensitizer by in situ acid‐triggered nano‐aggregates formation.