Open AccessCancer Chemotherapy: Redox‐Responsive Dual Drug Delivery Nanosystem Suppresses Cancer Repopulation by Abrogating Doxorubicin‐Promoted Cancer Stemness, Metastasis, and Drug Resistance (Adv. Sci. 7/2019)
Author(s) -
Liu Jia,
Chang Bingcheng,
Li Qilin,
Xu Luming,
Liu Xingxin,
Wang Guobin,
Wang Zheng,
Wang Lin
Publication year - 2019
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201970043
Subject(s) - doxorubicin , cancer , metastasis , chemotherapy , drug resistance , cancer research , cancer stem cell , cancer cell , medicine , drug delivery , drug , pharmacology , chemistry , biology , microbiology and biotechnology , organic chemistry
Chemotherapy effectiveness is greatly challenged by chemodrugs' intrinsic pathological interactions with tumor cells, which enhance cancer stemness, invasiveness and acquired drug resistance. In article number 1801987 , Guobin Wang, Zheng Wang, Lin Wang, and co‐workers construct a redox‐responsive, celecoxib‐modified nanosystem that efficiently enhances doxorubicin‐based chemotherapy and suppresses cancer repopulation by abrogating doxorubicin‐induced enhancement of cancer stemness, metastasis and drug resistance.