Open AccessBiohybrid Circuits: Biofunctionalized Materials Featuring Feedforward and Feedback Circuits Exemplified by the Detection of Botulinum Toxin A (Adv. Sci. 4/2019)
Author(s) -
Wagner Hanna J.,
Kemmer Svenja,
Engesser Raphael,
Timmer Jens,
Weber Wilfried
Publication year - 2019
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201970020
Subject(s) - electronic circuit , feed forward , stimulus (psychology) , network topology , nanotechnology , computer science , botulinum toxin , materials science , neuroscience , engineering , biology , control engineering , psychology , electrical engineering , psychotherapist , operating system
In article number 1801320 , Wilfried Weber and co‐workers present the incorporation of biological circuits into polymer materials capable of sensing and processing an input stimulus and producing a quantitative output. Positive feedback and/or feedforward network topologies detect the proteolytic activity of botulinum toxin A with adjustable kinetics and dynamic range. Image credit: Jo Richers ( www.jorichers.com ).