Open AccessHigh Efficiency BMP‐2 Coatings: Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects (Adv. Sci. 2/2019)
Author(s) -
Cheng Zhe A.,
AlbaPerez Andres,
GonzalezGarcia Cristina,
Donnelly Hannah,
LlopisHernandez Virginia,
Jayawarna Vineetha,
Childs Peter,
Shields David W.,
Cantini Marco,
RuizCantu Laura,
Reid Andrew,
Windmill James F. C.,
Addison Elena S.,
Corr Sandra,
Marshall William G.,
Dalby Matthew J.,
SalmeronSanchez Manuel
Publication year - 2019
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201970009
Subject(s) - fibronectin , regeneration (biology) , bone morphogenetic protein 2 , materials science , integrin , bone morphogenetic protein , microbiology and biotechnology , nanotechnology , biomedical engineering , cell , chemistry , medicine , biochemistry , biology , gene , in vitro
In article number 1800361 , Matthew J. Dalby, Manuel Salmeron‐Sanchez, and co‐workers coat structural material, e.g., particles or scaffolds, with a bioactive synthetic material that organizes fibronectin to present BMP‐2 with high efficiency. This is used as a novel regenerative approach to heal critical‐sized bone defects. Simultaneous integrin and growth factor receptor synergistic signaling drives stem cell differentiation leading to bone regeneration in the first veterinary patient. Image credit: Aleixandre Rodrigo‐Navarro and Sara Trujillo‐Muñoz.