Open AccessHyperthermia‐Triggered On‐Demand Biomimetic Nanocarriers for Synergetic Photothermal and Chemotherapy
Author(s) -
Gao Junbin,
Wang Fei,
Wang Shuanghu,
Liu Lu,
Liu Kun,
Ye Yicheng,
Wang Zhen,
Wang Hong,
Chen Bin,
Jiang Jiamiao,
Ou Juanfeng,
Hest Jan C. M.,
Peng Fei,
Tu Yingfeng
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201903642
Subject(s) - photothermal therapy , nanocarriers , nanogel , drug delivery , doxorubicin , photothermal effect , nanotechnology , hyaluronic acid , tumor microenvironment , chemistry , materials science , cancer research , chemotherapy , medicine , tumor cells , surgery , anatomy
Nanoparticle‐based drug delivery systems with low side effects and enhanced efficacy hold great potential in the treatment of various malignancies, in particular cancer; however, they are still challenging to attain. Herein, an anticancer drug delivery system based on a cisplatin (CDDP) containing nanogel, functionalized with photothermal gold nanorods (GNRs) which are electrostatically decorated with doxorubicin (DOX) is reported. The nanoparticles are formed via the crosslinking reaction of hyaluronic acid with the ancillary anticarcinogen CDDP in the presence of DOX‐decorated GNRs. The nanogel is furthermore cloaked with a cancer cell membrane, and the resulting biomimetic nanocarrier (4T1‐HANG‐GNR‐DC) shows efficient accumulation by homologous tumor targeting and possesses long‐time retention in the tumor microenvironment. Upon near‐infrared (NIR) laser irradiation, in situ photothermal therapy is conducted which further induces hyperthermia‐triggered on‐demand drug release from the nanogel reservoir to achieve a synergistic photothermal/chemo‐therapy. The as‐developed biomimetic nanocarriers, with their dual‐drug delivery features, homotypic tumor targeting and synergetic photothermal/chemo‐therapy, show much promise as a potential platform for cancer treatment.