Open AccessAuger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy
Author(s) -
Su Weiwei,
Wang Han,
Wang Tao,
Li Xiao,
Tang Zhongmin,
Zhao Shuai,
Zhang Meng,
Li Danni,
Jiang Xingwu,
Gong Teng,
Yang Wei,
Zuo Changjing,
Wu Yelin,
Bu Wenbo
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201903585
Subject(s) - nanomaterial based catalyst , radiolysis , catalysis , electron , chemistry , materials science , radical , nanoparticle , nanotechnology , radiochemistry , photochemistry , organic chemistry , physics , nuclear physics
Excess electrons play important roles for the construction of superficial active sites on nanocatalysts. However, providing excess electrons to nanocatalysts in vivo is still a challenge, which limits the applications of nanocatalysts in biomedicine. Herein, auger electrons (AEs) emitted from radionuclide 125 ( 125 I) are used in situ to construct active sites in a nanocatalyst (TiO 2 ) and the application of this method is further extended to cancer catalytic internal radiotherapy (CIRT). The obtained 125 I‐TiO 2 nanoparticles first construct superficial Ti 3+ active sites via the reaction between Ti 4+ and AEs. Then Ti 3+ stretches and weakens the OH bond of the absorbed H 2 O, thus enhancing the radiolysis of H 2 O molecules and generating hydroxyl radicals (•OH). All in vitro and in vivo results demonstrate a good CIRT performance. These findings will broaden the application of radionuclides and introduce new perspectives to nanomedicine.