Open AccessNear‐Infrared Chemiluminescent Carbon Nanodots and Their Application in Reactive Oxygen Species Bioimaging
Author(s) -
Shen ChengLong,
Lou Qing,
Zang JinHao,
Liu KaiKai,
Qu SongNan,
Dong Lin,
Shan ChongXin
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201903525
Subject(s) - nanodot , chemiluminescence , reactive oxygen species , hydrogen peroxide , quantum yield , near infrared spectroscopy , detection limit , materials science , oxygen , in vivo , nanotechnology , photochemistry , chemistry , fluorescence , optics , organic chemistry , biochemistry , physics , chromatography , microbiology and biotechnology , biology
Reactive oxygen species (ROS) are generated in the body and related to many pathophysiological processes. Hence, detection of ROS is indispensable in understanding, diagnosis, and treatment of many diseases. Here, near‐infrared (NIR) chemiluminescent (CL) carbon nanodots (CDs) are fabricated for the first time and their CL quantum yield can reach 9.98 × 10 −3 einstein mol −1 , which is the highest value ever reported for CDs until now. Nanointegration of NIR CDs and peroxalate (P‐CDs) through the bridging effect of amphiphilic triblock copolymer can serve as turn‐on probes for the detection and imaging of hydrogen peroxide (H 2 O 2 ). Considering high efficiency and large penetration depth of NIR photons, the P‐CDs are employed in bioimaging H 2 O 2 in vitro and in vivo, and the detection limit can reach 5 × 10 −9 m , among the best reported of CDs‐based sensors. Moreover, imaging of inflammatory H 2 O 2 in a mouse model of peritonitis is achieved by employing the P‐CDs as sensors. The results may provide a clue for the diagnosis and treatment of inflammation or cancers employing CL CDs as sensors.