Open AccessProgrammable ROS‐Mediated Cancer Therapy via Magneto‐Inductions
Author(s) -
Wu Jiaojiao,
Ning Peng,
Gao Rui,
Feng Qishuai,
Shen Yajing,
Zhang Yifan,
Li Yingze,
Xu Chang,
Qin Yao,
Plaza Gustavo R.,
Bai Qianwen,
Fan Xing,
Li Zhenguang,
Han Yu,
Lesniak Maciej S.,
Fan Haiming,
Cheng Yu
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201902933
Subject(s) - reactive oxygen species , intracellular , oxidative stress , cancer cell , cancer , apoptosis , mitochondrion , cancer therapy , mitochondrial ros , cancer treatment , cancer research , in vivo , biophysics , chemistry , microbiology and biotechnology , materials science , nanotechnology , medicine , biochemistry , biology
Reactive oxygen species (ROS), a group of oxygen derived radicals and derivatives, can induce cancer cell death via elevated oxidative stress. A spatiotemporal approach with safe and deep‐tissue penetration capabilities to elevate the intracellular ROS level is highly desirable for precise cancer treatment. Here, a mechanical‐thermal induction therapy (MTIT) strategy is developed for a programmable increase of ROS levels in cancer cells via assembly of magnetic nanocubes integrated with alternating magnetic fields. The magneto‐based mechanical and thermal stimuli can disrupt the lysosomes, which sequentially induce the dysfunction of mitochondria. Importantly, intracellular ROS concentrations are responsive to the magneto‐triggers and play a key role for synergistic cancer treatment. In vivo experiments reveal the effectiveness of MTIT for efficient eradication of glioma and breast cancer. By remote control of the force and heat using magnetic nanocubes, MTIT is a promising physical approach to trigger the biochemical responses for precise cancer treatment.