Open AccessConsiderations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections
Author(s) -
Ma YuXuan,
Wang ChenYu,
Li YuanYuan,
Li Jing,
Wan QianQian,
Chen JiHua,
Tay Franklin R.,
Niu LiNa
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201901872
Subject(s) - acinetobacter baumannii , enterococcus faecium , pseudomonas aeruginosa , klebsiella pneumoniae , microbiology and biotechnology , staphylococcus aureus , antimicrobial , enterobacter , antibiotic resistance , enterococcus , acinetobacter , antibiotics , medicine , biology , bacteria , escherichia coli , biochemistry , genetics , gene
ESKAPE pathogens ( Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , and Enterobacter species) are among the most common opportunistic pathogens in nosocomial infections. ESKAPE pathogens distinguish themselves from normal ones by developing a high level of antibiotic resistance that involves multiple mechanisms. Contemporary therapeutic strategies which are potential options in combating ESKAPE bacteria need further investigation. Herein, a broad overview of the antimicrobial research on ESKAPE pathogens over the past five years is provided with prospective clinical applications.