Open AccessPreparation of Scalable Silica‐Coated Iron Oxide Nanoparticles for Nanowarming
Author(s) -
Gao Zhe,
Ring Hattie L.,
Sharma Anirudh,
Namsrai Baterdene,
Tran Nam,
Finger Erik B.,
Garwood Michael,
Haynes Christy L.,
Bischof John C.
Publication year - 2020
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201901624
Subject(s) - biocompatibility , microporous material , nanoparticle , materials science , iron oxide nanoparticles , iron oxide , mesoporous silica , microscale chemistry , biomedical engineering , nanotechnology , chemical engineering , chemistry , mesoporous material , metallurgy , composite material , engineering , medicine , biochemistry , mathematics education , mathematics , catalysis
Cryopreservation technology allows long‐term banking of biological systems. However, a major challenge to cryopreserving organs remains in the rewarming of large volumes (>3 mL), where mechanical stress and ice formation during convective warming cause severe damage. Nanowarming technology presents a promising solution to rewarm organs rapidly and uniformly via inductive heating of magnetic nanoparticles (IONPs) preloaded by perfusion into the organ vasculature. This use requires the IONPs to be produced at scale, heat quickly, be nontoxic, remain stable in cryoprotective agents (CPAs), and be washed out easily after nanowarming. Nanowarming of cells and blood vessels using a mesoporous silica‐coated iron oxide nanoparticle (msIONP) in VS55, a common CPA, has been previously demonstrated. However, production of msIONPs is a lengthy, multistep process and provides only mg Fe per batch. Here, a new microporous silica‐coated iron oxide nanoparticle (sIONP) that can be produced in as little as 1 d while scaling up to 1.4 g Fe per batch is presented. sIONP high heating, biocompatibility, and stability in VS55 is also verified, and the ability to perfusion load and washout sIONPs from a rat kidney as evidenced by advanced imaging and ICP‐OES is demonstrated.