Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy | Zendy

Zhang Fengrong | Zendy; Liu Yuehong | Zendy; Lei Jiani | Zendy; Wang Shunhao | Zendy; Ji Xunming | Zendy; Liu Huiyu | Zendy; Yang Qi | Zendy

Open Access

Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy

Author(s) -

Zhang Fengrong,

Liu Yuehong,

Lei Jiani,

Wang Shunhao,

Ji Xunming,

Liu Huiyu,

Yang Qi

Publication year - 2019

Publication title -

advanced science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.388

H-Index - 100

ISSN - 2198-3844

DOI - 10.1002/advs.201901378

Subject(s) - photothermal therapy , photodynamic therapy , nanostructure , materials science , metal organic framework , modality (human–computer interaction) , nanotechnology , thrombus , carbon fibers , dual (grammatical number) , chemistry , medicine , composite material , computer science , adsorption , organic chemistry , art , literature , human–computer interaction , composite number

Although near‐infrared (NIR)‐light‐mediated photothermal thrombolysis has been investigated to overcome the bleeding risk of clinical clot‐busting agents, the secondary embolism of post‐phototherapy fragments (>10 µm) for small vessels should not be ignored in this process. In this study, dual‐modality photothermal/photodynamic thrombolysis is explored using targeting nanoagents with an emphasis on improving biosafety as well as ameliorating the thrombolytic effect. The nanoagents can actively target glycoprotein IIb/IIIa receptors on thrombus to initiate site‐specific thrombolysis by hyperthermia and reactive oxygen species under NIR laser irradiation. In comparison to single photothermal thrombolysis, an 87.9% higher re‐establishment rate of dual‐modality photothermal/photodynamic thrombolysis by one‐time treatment is achieved in a lower limb thrombosis model. The dual‐modality thrombolysis can also avoid re‐embolization after breaking fibrin into tiny fragments. All the results show that this strategy is a safe and validated protocol for thrombolysis, which fits the clinical translational trend of nanomedicine.

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