Open AccessSelective Killing of Cancer Cells by Nonplanar Aromatic Hydrocarbon‐Induced DNA Damage
Author(s) -
Zhou Yan,
Gan Fuwei,
Zhang Yuanliang,
He Xiaozhen,
Shen Chengshuo,
Qiu Huibin,
Liu Peifeng
Publication year - 2019
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201901341
Subject(s) - cancer cell , cytotoxicity , dna , dna damage , apoptosis , cancer research , cancer , liver cancer , chemistry , leukemia , lung cancer , carcinogen , dna synthesis , cell , biology , biochemistry , in vitro , immunology , medicine , pathology , genetics
A large number of current chemotherapeutic agents prevent the growth of tumors by inhibiting DNA synthesis of cancer cells. It has been found recently that many planar polycyclic aromatic hydrocarbons (PAHs) derivatives, previously known as carcinogenic, display anticancer activity through DNA cross‐linking. However, the practical use of these PAHs is substantially limited by their low therapeutic efficiency and selectivity toward most tumors. Herein, the anticancer property of a nonplanar PAH named [4]helicenium, which exhibits highly selective cytotoxicity toward liver, lung cancer, and leukemia cells compared with normal cells, is reported. Moreover, [4]helicenium effectively inhibits tumor growth in liver cancer‐bearing mice and shows little side effects in normal mice. RNA sequencing and confirmatory results demonstrate that [4]helicenium induces more DNA damage in tumor cells than in normal cells, resulting in tumor cell cycle arrest and apoptosis increment. This study reveals an unexpected role and molecular mechanism for PAHs in selectively killing tumor cells and provides an effective strategy for precision cancer therapies.