Open AccessTargeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies
Author(s) -
Pesarrodona Mireia,
Jauset Toni,
DíazRiascos Zamira V.,
SánchezChardi Alejandro,
Beaulieu MarieEve,
SerasFranzoso Joaquin,
SánchezGarcía Laura,
BaltàFoix Ricardo,
Mancilla Sandra,
Fernández Yolanda,
Rinas Ursula,
Schwartz Simó,
Soucek Laura,
Villaverde Antonio,
Abasolo Ibane,
Vázquez Esther
Publication year - 2019
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201900849
Subject(s) - breast cancer , inclusion (mineral) , cancer , cancer research , medicine , administration (probate law) , pharmacology , chemistry , political science , mineralogy , law
Two structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44‐targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types of protein materials selectively penetrate and kill CD44 + tumor cells in culture, and upon local administration, promote destruction of tumoral tissue in orthotropic mouse models of human breast cancer. These findings support the concept of bacterial inclusion bodies as versatile protein materials suitable for application in chronic diseases that, like cancer, can benefit from a local slow release of therapeutic proteins.