Open AccessEngineering Cell Membrane‐Based Nanotherapeutics to Target Inflammation
Author(s) -
Yan Huize,
Shao Dan,
Lao YehHsing,
Li Mingqiang,
Hu Hanze,
Leong Kam W.
Publication year - 2019
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201900605
Subject(s) - nanomedicine , inflammation , immune system , cell , nanotechnology , microbiology and biotechnology , chemistry , medicine , materials science , biology , immunology , nanoparticle , biochemistry
Inflammation is ubiquitous in the body, triggering desirable immune response to defend against dangerous signals or instigating undesirable damage to cells and tissues to cause disease. Nanomedicine holds exciting potential in modulating inflammation. In particular, cell membranes derived from cells involved in the inflammatory process may be used to coat nanotherapeutics for effective targeted delivery to inflammatory tissues. Herein, the recent progress of rationally engineering cell membrane‐based nanotherapeutics for inflammation therapy is highlighted, and the challenges and opportunities presented in realizing the full potential of cell‐membrane coating in targeting and manipulating the inflammatory microenvironment are discussed.