Open AccessTrimodal Therapy: A Tumor Vascular‐Targeted Interlocking Trimodal Nanosystem That Induces and Exploits Hypoxia (Adv. Sci. 8/2018)
Author(s) -
Luan Xin,
Guan YingYun,
Liu HaiJun,
Lu Qin,
Zhao Mei,
Sun Duxin,
Lovell Jonathan F.,
Sun Peng,
Chen HongZhuan,
Fang Chao
Publication year - 2018
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201870048
Subject(s) - interlocking , hypoxia (environmental) , prodrug , photodynamic therapy , exploit , cancer research , nanotechnology , medicine , chemistry , materials science , pharmacology , computer science , engineering , oxygen , mechanical engineering , computer security , organic chemistry
A tumor vascular‐targeted interlocking trimodal nanosystem that induces and exploits hypoxia is described by Hong‐Zhuan Chen, Chao Fang, and co‐workers in article number 1800034 . In the image, the two streams of water from bamboo pipes and the rotary waterwheel are shown to represent verteporfin for vascular‐targeted photodynamic treatment and HIF‐1α siRNA for elevated activating reductases (CYP450), which can trigger the activation of AQ4N (a hypoxia‐activated prodrug).