Open AccessTissue Engineering: A Modular Strategy to Engineer Complex Tissues and Organs (Adv. Sci. 5/2018)
Author(s) -
Dikina Anna D.,
Alt Daniel S.,
Herberg Samuel,
McMillan Alexandra,
Strobel Hannah A.,
Zheng Zijie,
Cao Meng,
Lai Bradley P.,
Jeon Oju,
Petsinger Victoria Ivy,
Cotton Calvin U.,
Rolle Marsha W.,
Alsberg Eben
Publication year - 2018
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201870028
Subject(s) - scaffold , tissue engineering , modular design , cartilage , biomedical engineering , construct (python library) , chemistry , anatomy , microbiology and biotechnology , computer science , biology , medicine , operating system , programming language
In article number 1700402 , Eben Alsberg and co‐workers report the engineering of tri‐tissue tracheas using a scaffold‐free approach that allows for the integration of structural cartilage rings, prevascular blood vessel networks, and epithelial cells into a single construct. Neotracheas of various dimensions, including human size, are formed via cellular self‐assembly. Prevascular tracheas are subcutaneously implanted into mice and demonstrate anastamosis with and perfusion by host vasculature.