Open AccessOrganelle Transplantation: Polymer Functionalization of Isolated Mitochondria for Cellular Transplantation and Metabolic Phenotype Alteration (Adv. Sci. 3/2018)
Author(s) -
Wu Suhong,
Zhang Aijun,
Li Shumin,
Chatterjee Somik,
Qi Ruogu,
SeguraIbarra Victor,
Ferrari Mauro,
Gupte Anisha,
Blanco Elvin,
Hamilton Dale J.
Publication year - 2018
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201870017
Subject(s) - mitochondrion , organelle , transplantation , ex vivo , conjugate , phenotype , microbiology and biotechnology , surface modification , chemistry , in vivo , biology , biochemistry , in vitro , medicine , gene , genetics , mathematical analysis , mathematics
Isolated mitochondria are polymerically functionalized for transplantation into metabolically compromised cells. In article number 1700530 , Elvin Blanco, Dale J. Hamilton, and co‐workers demonstrate that coating mitochondria with a dextran‐triphenylphosphonium (TPP) conjugate results in longer functional survival of the organelle ex vivo, increased cellular uptake, and an enhanced shift in the metabolic phenotype of cells compared to uncoated mitochondria.