Open AccessNucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
Author(s) -
Krüger Franziska,
Kumar Vipin,
Monge Pere,
Conzelmann Carina,
Smith Nikaïa,
Gothelf Kurt V.,
Tolstrup Martin,
Münch Jan,
Zelikin Alexander N.
Publication year - 2019
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201802095
Subject(s) - phosphodiester bond , nucleic acid , prodrug , deoxyribose , nucleoside , chemistry , macromolecule , combinatorial chemistry , nucleoside analogue , anticancer drug , biochemistry , drug , rna , biology , pharmacology , gene
Abstract Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.