Open AccessPolydopamine‐Modified Black Phosphorous Nanocapsule with Enhanced Stability and Photothermal Performance for Tumor Multimodal Treatments
Author(s) -
Zeng Xiaowei,
Luo Miaomiao,
Liu Gan,
Wang Xusheng,
Tao Wei,
Lin Yaoxin,
Ji Xiaoyuan,
Nie Lin,
Mei Lin
Publication year - 2018
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201800510
Subject(s) - photothermal therapy , black phosphorus , nanotechnology , materials science , drug delivery , photothermal effect , cancer therapy , in vivo , surface modification , nanocapsules , cancer , chemistry , nanoparticle , medicine , biology , microbiology and biotechnology , optoelectronics
As a novel 2D material, black phosphorus (BP) nanosheets are considered as a promising candidate for drug delivery platform for synergistic chemo/photothermal therapy. However, the intrinsic instability of bare BP poses a challenge in its biomedical applications. To date, some strategies have been employed to prevent BP from rapid ambient degradation. Unfortunately, most of these strategies are not suitable for the drug delivery systems. Here, a simple polydopamine modification method is developed to enhance the stability and photothermal performance of bare BP nanosheets. Then, this nanocapsule is used as a multifunctional codelivery system for the targeted chemo, gene, and photothermal therapy against multidrug‐resistant cancer. The enhanced tumor therapy effect is demonstrated by both in vitro and in vivo studies.