Open AccessMitochondria‐Targeted Artificial “Nano‐RBCs” for Amplified Synergistic Cancer Phototherapy by a Single NIR Irradiation
Author(s) -
Zhang Liang,
Wang Dong,
Yang Ke,
Sheng Danli,
Tan Bin,
Wang Zhigang,
Ran Haitao,
Yi Hengjing,
Zhong Yixin,
Lin Han,
Chen Yu
Publication year - 2018
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201800049
Subject(s) - photodynamic therapy , photothermal therapy , cancer cell , photoacoustic imaging in biomedicine , nanomedicine , fluorescence lifetime imaging microscopy , tumor hypoxia , cancer , cancer therapy , radiation therapy , nanotechnology , materials science , nanoparticle , chemistry , fluorescence , medicine , surgery , physics , organic chemistry , quantum mechanics , optics
Phototherapy has emerged as a novel therapeutic modality for cancer treatment, but its low therapeutic efficacy severely hinders further extensive clinical translation and application. This study reports amplifying the phototherapeutic efficacy by constructing a near‐infrared (NIR)‐responsive multifunctional nanoplatform for synergistic cancer phototherapy by a single NIR irradiation, which can concurrently achieve mitochondria‐targeting phototherapy, synergistic photothermal therapy (PTT)/photodynamic therapy (PDT), self‐sufficient oxygen‐augmented PDT, and multiple‐imaging guidance/monitoring. Perfluorooctyl bromide based nanoliposomes are constructed for oxygen delivery into tumors, performing the functions of red blood cells (RBCs) for oxygen delivery (“Nano‐RBC” nanosystem), which can alleviate the tumor hypoxia and enhance the PDT efficacy. The mitochondria‐targeting performance for enhanced and synergistic PDT/PTT is demonstrated as assisted by nanoliposomes. In particular, these “Nano‐RBCs” can also act as the contrast agents for concurrent computed tomography, photoacoustic, and fluorescence multiple imaging, providing the potential imaging capability for phototherapeutic guidance and monitoring. This provides a novel strategy to achieve high therapeutic efficacy of phototherapy by the rational design of multifunctional nanoplatforms with the unique performances of mitochondria targeting, synergistic PDT/PTT by a single NIR irradiation (808 nm), self‐sufficient oxygen‐augmented PDT, and multiple‐imaging guidance/monitoring.