Open AccessBiocompatibility of Nanoparticles: Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes (Adv. Sci. 12/2017)
Author(s) -
Zhao Xingchen,
Lu Dawei,
Liu Qian S.,
Li Yiling,
Feng Rui,
Hao Fang,
Qu Guangbo,
Zhou Qunfang,
Jiang Guibin
Publication year - 2017
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.201770058
Subject(s) - biocompatibility , hemolysis , hemoglobin , nanorod , nanotechnology , nanoparticle , chemistry , colloidal gold , biophysics , materials science , biochemistry , medicine , immunology , biology , organic chemistry
In article 1700296 , Qunfang Zhou and co‐workers report the hemocompatibility of gold nanorods (GNRs). In contrast to negatively charged GNRs, positively charged GNRs (C‐GNRs) induce instant hemolysis. After cellular encapsulation, the GNRs are found to bind with hemoglobin and to induce conformational and functional changes in the protein. This demonstrates that surface modification holds great promise as an approach to improve the biocompatibility of GNRs for clinical use.